Alt a 1. New approach for the diagnosis and treatment of allergy to Alternaria alternata
نویسنده
چکیده
More than 3 billion people worldwide are infected with parasitic worms called helminthes or suffer allergic disorders such as asthma, allergic rhinitis, food allergies and eczema. A common feature of these infectious or inflammatory conditions is the called allergic or “type 2” immune response. Type 2 immune responses are induced by and confer protection against helminthes, but can also play pathologic roles, promoting acute and chronic inflammatory responses against a miryad of allergens 1
منابع مشابه
Orthologous Allergens and Diagnostic Utility of Major Allergen Alt a 1
PURPOSE Hypersensitivity to fungi is associated with rhinoconjunctivitis and asthma. For some fungi, such as Alternaria alternata (A. alternata), the symptoms of asthma are persistent, increasing disease severity and the risk of fatal outcomes. There are a large number of species of fungi but knowledge of them remains limited. This, together with the difficulties in obtaining adequate standardi...
متن کاملAlternaria alternata allergens: Markers of exposure, phylogeny and risk of fungi-induced respiratory allergy.
Alternaria alternata spores are considered a well-known biological contaminant and a very common potent aeroallergen source that is found in environmental samples. The most intense exposure to A. alternata allergens is likely to occur outdoors; however, Alternaria and other allergenic fungi can colonize in indoor environments and thereby increase the fungal aeroallergen exposure levels. A conse...
متن کاملCorrelation between Alt a 1 levels and clinical symptoms in Alternaria alternata-monosensitized patients.
BACKGROUND Alternaria alternata is a risk factor for developing asthma.Alt a 1, which has been described as the major allergen in A alternata, shows a good correlation with A alternata spores only when they have germinated. OBJECTIVES The objective of this study was to determine the correlation between spore counts and clinical symptoms in patients with allergic asthma and/or rhinitis monosen...
متن کاملSpecific Antibodies for the Detection of Alternaria Allergens and the Identification of Cross-Reactive Antigens in Other Fungi
BACKGROUND The mould Alternaria alternata is an important source of respiratory allergens. A. alternata extracts show great variations regarding allergenic potency. The aim of this study was to generate antibody probes specific for important Alternaria allergens and to use them to study allergen expression, depending on different culture conditions, as well as to search for cross-reactive aller...
متن کاملVariability of Alt a 1 expression by different strains of Alternaria alternata.
BACKGROUND While it is well known that there is significant intraspecific variation in the content an potency of Alternaria alternata allergens, little data has been published on intraspecific variability for individual allergens from moulds. OBJECTIVE To assess the variability of Alt a 1 expression in different strains of A alternata. METHODS Eleven strains of A alternata were cultured in ...
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